ADC Development: Targeted Treatment
The use of antibody-drug conjugates has become particularly prevalent in cancer therapy, although their development can be problematic in their execution. However, aptamers can be used as alternative affinity ligands to overcome these drawbacks. A piece in EBR, authored by the team at Aptamer Group discusses more.
Aptamers have an additional advantage as they are typically 5-10-fold smaller than antibodies, allowing greater tissue penetration and cellular uptake.