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Insight

Aptamers as protein-protein interaction inhibitors

Protein-protein interactions were once considered undruggable. Our tailored aptamer selection approach is proving this isn’t so. Targets such as transcription factors, immune checkpoints in oncology, infectious disease agents, and…

Celebrating DNA aptamers on DNA Day!

April 25th is DNA day. This day celebrates the completion of the Human Genome Project 20 years ago and the discovery of DNA’s double helix 70 years ago,…

The stability of aptamers

One of the key benefits of using aptamers instead of antibodies is how you store and use your reagent. Over the past 60 years the stability of oligonucleotides has…

Constrained Optimer structures for increased performance

Constraining an Optimer to a specific structure confers various benefits to the ligand that researchers can use for increased assay performance. Constrained Optimer structures Optimer binders are single-stranded oligonucleotides that can…