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Synthetic Chemist

Aptamer Group > Careers > Synthetic Chemist

Synthetic Chemist

Location: York UK

Role: Full time, permanent

We are growing and growing fast. Aptamer Group is a leading developer of next-generation molecular tools to enable innovation across the life sciences. We employ a diverse and talented team of high calibre scientists and commercial professionals located at our state-of-the-art development facility in York, UK.

Job Description

The Synthetic Chemist will play a key role in our aptamer production workflow, they will be working closely with both the production and R&D team to fulfil customer and research related goals. The successful candidate will be responsible for the design, synthesis, and analysis of oligonucleotides.

Required Duties and Responsibilities:

  • Design and perform automated high throughput solid-phase synthesis, purification, and analysis of novel oligonucleotides with chemical modifications (training will be provided)
  • Operate and maintain oligonucleotide synthesis platforms
  • Perform analysis of oligonucleotides by LCMS and other scientific equipment
  • Perform method/process development for improved oligonucleotide synthesis and purification processes
  • Author standard operating procedures and maintain well documented records

Required Skills and Expertise

  • A PhD in synthetic organic or medicinal chemistry. Candidates without a PhD with strong experience in industry will also be considered
  • Excellent practical skills including handling of air- and moisture-sensitive materials
  • Excellent knowledge of chemical transformations, retrosynthesis and reaction mechanisms
  • Proven ability to conduct self-directed research, troubleshooting and work effectively in a dynamic environment with a diverse team

Desirable Skills and Expertise

  • Expertise in the synthesis, purification, and analysis of oligonucleotides
  • Experience in development, production, and purification of novel phosphoramidites for integration into oligo synthesis workflows
  • Good knowledge of chemical modifications of oligonucleotides
  • Experience in solid phase synthesis
  • Experience in using LCMS instrumentation
  • Data interpretation skills for NMR and LCMS
  • Knowledge of aptamer therapeutics, aptamer generation, or aptamer discovery

Salary and benefits

  • Salary range: £27,500-£31,500
  • 25 days annual leave plus bank holidays
  • Employer contributions pension scheme
  • Gym membership (David Lloyds)
  • Private Healthcare
  • Free on-site car parking
  • Regular team events
  • Located in one of the best cities in the UK

Interested? We’d Love to hear from you!

Please apply using the button below, with a copy of your CV and a covering letter.

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