Skip to content

Head of Chemistry (Synthesis)

Aptamer Group > Careers > Head of Chemistry (Synthesis)

Head of Chemistry (Synthesis)

We are growing and growing fast. We employ a diverse and talented team of high calibre scientists, operational, commercial & financial professionals located at our state-of-the-art development facility in York, UK.

We are currently expanding our team and are looking for an organised and experienced professional to lead our Chemistry initiatives at Aptamer Group plc. This position will report to the Scientific Operations Director.


The Head of Chemistry (Synthesis) is an integral part of the operational leadership team, reporting to the Scientific Operations Director and working closely with other Heads of Departments. This is a challenging role within a dynamic environment, with many responsibilities, including delivering in-house synthesis of aptamers for internal and external projects, leading the successful implementation of proprietary platform technologies, and providing chemistry expertise to support external customer projects and internal research and development.


Department: Synthesis

Reports to: Scientific Operations Director

Direct Reports: Synthesis Team


Main responsibilities

  • Oversee day-to-day operations in the synthesis laboratory and ensure equipment and necessary reagent stocks are maintained.
  • Supervise synthesis of aptamers to enable timely delivery of both internal and external projects
  • Provide leadership & mentoring to the Synthesis team
  • Ensure the Synthesis team is high performing, efficient and accountable
  • Ensure smooth running and provide hands-on troubleshooting of Synthesis and analytical equipment
  • Author Work Instructions for aptamer synthesis, purification, and analysis
  • Provide expertise across AGL on oligo synthesis and related chemistries to assist with production and R&D projects
  • Lead process improvements within the Synthesis department
  • Work closely with technology providers to identify new equipment to expand synthesis capabilities at Aptamer Group
  • Lead the development of new synthesis intellectual property
  • Assist with project planning and costings for internal and external synthesis projects
  • Ensure that all Synthesis activities comply with Health & Safety requirements
  • Ensure that all Synthesis activities comply with Quality Management System
  • Perform any other reasonable tasks and duties as assigned by the Scientific Operation Director.


Essential Skills & Expertise

  • An excellent working knowledge of oligonucleotide synthesis, including optimisation and troubleshooting
  • Excellent working knowledge of purification and analytical techniques
  • Experience in development, production, and purification of novel phosphoramidites for integration into oligo synthesis workflows
  • Strong communication skills both written and verbal and active listener.
  • Resilient, calm, action-oriented individual that can work under pressure in a fast-paced entrepreneurial environment using a common sense approach to ensure timely project delivery.
  • Ability to juggle several projects concurrently with ability to pay attention to details, yet still execute within required project timescales, using time and people management skills.
  • Previous experience working with Project Management tools e.g., Microsoft Project.
  • Strong sense of urgency with proven success in driving change culture/ scientific innovations.
  • Ability to relate and communicate clearly with customers, stakeholders, and differing levels of staff within an organisation.
  • Demonstrate highest standards of scientific integrity and professionalism.
  • Promote positive, collaborative working attitude

     Personal Qualifications /Industrial Experience

  • PhD or Post Doc in Synthetic or medicinal chemistry or a related subject.
  • Minimum of 5 years’ industrial experience
  • Experience of working in multi-disciplinary teams to deliver therapeutically useful products.

     Remuneration Package 

  • Competitive salary
  • Private Healthcare
  • Onsite parking
  • Company Pension
  • Gym Membership

Interested? We’d love to hear from you!

Please apply using the button below, with a copy of your CV and a covering letter.

Start your next project with Aptamer Group

Contact one of our experts today